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Related Experiment Videos

Activated leukocytes and the hemostatic system.

E F Lüscher1

  • 1Theodor Kocher Institute, University of Bern, Switzerland.

Reviews of Infectious Diseases
|September 1, 1987
PubMed
Summary
This summary is machine-generated.

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Activated leukocytes initiate blood clotting and can degrade clotting factors. These immune cells and their products contribute to hemostatic disorders like disseminated intravascular coagulation.

Area of Science:

  • Immunology
  • Hematology
  • Biochemistry

Background:

  • Activated leukocytes influence the blood-clotting system.
  • Macrophages and monocytes release tissue thromboplastin upon stimulation.

Purpose of the Study:

  • To elucidate the multifaceted roles of activated leukocytes and their products in hemostasis.
  • To highlight the involvement of leukocytes in the pathogenesis of coagulation disorders.

Main Methods:

  • Analysis of leukocyte-derived procoagulant and anticoagulant activities.
  • Investigation of leukocyte protease interactions with clotting factors and platelets.
  • Assessment of platelet-activating factors and leukotrienes in platelet function.

Main Results:

Related Experiment Videos

  • Leukocytes synthesize and expose tissue thromboplastin, activating coagulation.
  • Leukocyte proteases degrade clotting factors (V, VIII, XIII) and fibrinogen, acting as fibrinolytic agents.
  • Leukocyte elastase modifies platelet receptors and promotes aggregation.
  • Leukocyte-derived platelet-activating factor and leukotrienes enhance platelet activity.

Conclusions:

  • Activated leukocytes are key players in initiating and modulating blood coagulation.
  • Leukocyte products significantly impact hemostasis, contributing to thrombotic and bleeding disorders.
  • Disseminated intravascular coagulation is a prominent example of leukocyte-mediated hemostatic dysfunction.