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Updated: Nov 30, 2025

Transuterine Fetal Tracheal Occlusion Model in Mice
Published on: February 5, 2021
Prognosis of conventional vs. high-frequency ventilation for congenital diaphragmatic hernia: a retrospective cohort
Makiko Fuyuki1,2, Noriaki Usui3, Tomoaki Taguchi4
1Department of Pediatrics, Osaka City University Graduate School of Medicine, Osaka, Japan. oldcoldwinter@yahoo.co.jp.
Objective:
To determine the appropriate initial ventilatory mode for neonatal congenital diaphragmatic hernia (CDH) by comparing patient prognosis following conventional mechanical ventilation (CMV) versus high-frequency oscillatory ventilation (HFO).
Study Design:
This multicenter retrospective cohort study was performed at 15 participating hospitals in Japan between 2011 and 2016. The 328 eligible CDH infants were classified into CMV (n = 78) and HFO groups (n = 250) to compare mortality and incidence of bronchopulmonary dysplasia (BPD). Propensity score matching was applied to reduce confounding by indication.
Result:
While crude mortality was significantly higher in the HFO than the CMV group, adjusted odds ratio (OR) did not show significant difference in mortality between groups (OR of HFO group: 0.98, 95% confidence interval (CI): 0.57-1.67). Adjusted OR of BPD incidence showed no significant difference between groups (OR of HFO group: 1.66, 95%CI: 0.50-5.49).
Conclusion:
Initial ventilatory mode in CDH patients, whether CMV or HFO, does not affect prognosis.
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