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Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach
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Equivocal, explicit and emergent actions of PKC isoforms in cancer

Peter J Parker1,2, Sophie J Brown3, Veronique Calleja3

  • 1Protein Phosphorylation Laboratory, Francis Crick Institute, London, UK. peter.parker@crick.ac.uk.

Nature Reviews. Cancer
|November 12, 2020
PubMed

Insights

Protein Kinase C (PKC) mutations in cancer are revealing new therapeutic targets. Understanding PKC

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Cancer genomes exhibit evolving mutational landscapes.
  • Protein Kinase C (PKC) family kinases play critical roles in cellular functions.
  • Tumor microenvironment significantly impacts cancer progression and treatment efficacy.

Purpose of the Study:

  • To explore novel features of the PKC family in cancer.
  • To investigate the implications of PKC mutations and their roles in tumorigenesis.
  • To assess the potential of targeting PKC isoforms within the tumor ecosystem.

Main Methods:

  • Analysis of cancer genome data.
  • Review of recent literature on PKC function and mutations.
  • Integration of insights into tumor microenvironment and immune interactions.

Main Results:

  • Gain or loss-of-function mutations in PKC are identified.
  • Conformational plasticity and constraints influence PKC activity.
  • PKC's role in stromal and immune cell functions is highlighted.

Conclusions:

  • Emergent cancer-associated properties of PKC offer therapeutic opportunities.
  • Targeting PKC isoforms requires careful consideration of timing and mechanism.
  • Integrating PKC-targeted therapies with immune checkpoint interventions may enhance efficacy.

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