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Updated: Nov 30, 2025

Detection of Disease-associated α-synuclein by Enhanced ELISA in the Brain of Transgenic Mice Overexpressing Human A53T Mutated α-synuclein

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Published on: May 30, 2015

Intracellular Alpha-Synuclein and Immune Cell Function.

Veselin Grozdanov¹, Karin M Danzer¹

¹Department of Neurology, Ulm University, Ulm, Germany.

Frontiers in Cell and Developmental Biology

|November 12, 2020

Summary

Alpha-synuclein impacts cell function, particularly in immune cells relevant to Parkinson's disease. Understanding its effects on immune cells is crucial for neurodegeneration research and developing new therapies.

Keywords:

Parkinson’s disease alpha-synuclein immune cell function microglia monocytes

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Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation

Published on: June 26, 2018

Area of Science:

Neuroscience
Immunology
Cell Biology

Background:

Intracellular alpha-synuclein affects various cellular functions, with most research focused on neuronal and glial cells.
The role of immune cells in Parkinson's disease and synucleinopathies is an emerging area of study.
Altered immune cell phenotypes and functions are observed in both animal models and human synucleinopathies.

Purpose of the Study:

To review the current knowledge on how alpha-synuclein affects immune cell phenotype and function.
To explore the impact of endogenously expressed or internalized alpha-synuclein on immune cells.
To discuss the potential of this research for advancing synucleinopathy understanding and therapy development.

Main Methods:

Literature review of studies investigating alpha-synuclein's effects on immune cells.
Analysis of research on both peripheral and central nervous system (CNS) immune cells.
Synthesis of findings related to alpha-synuclein pathology and immune cell function.

Main Results:

While extracellular alpha-synuclein's effects on immune cells are well-studied, internal alpha-synuclein's impact is less understood.
Evidence suggests alpha-synuclein pathology influences immune cell behavior in synucleinopathies.
Research highlights the need for further investigation into immune cell roles in neurodegenerative diseases.

Conclusions:

Alpha-synuclein's influence on immune cells is a critical, yet underexplored, aspect of synucleinopathies.
Understanding these interactions may unlock novel therapeutic strategies for Parkinson's disease.
Further research into alpha-synuclein's effects on immune cells is warranted.