Related Experiment Video

Updated: Nov 30, 2025

Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model
08:33

Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model

Published on: November 24, 2016

9.6K

The Incidence, Risk Factors and In-Hospital Mortality of Acute Kidney Injury in Patients After Surgery for Acute Type

Linji Li1,2, Jiaojiao Zhou3, Xuechao Hao1

  • 1Department of Anesthesiology, West China Hospital, Sichuan University & The Research Units of West China (2018RU012), Chinese Academy of Medical Sciences, Chengdu, China.

Frontiers in Medicine
|November 12, 2020
PubMed

Insights

Acute kidney injury (AKI) is common after acute type A aortic dissection (AAAD) surgery, affecting over 70% of patients and increasing mortality. Identifying risk factors for AKI and its associated mortality is crucial for improving patient outcomes.

Area of Science:

  • Cardiology
  • Nephrology
  • Surgical Outcomes

Background:

  • Acute kidney injury (AKI) is a frequent complication following cardiac surgery, associated with increased morbidity and mortality.
  • Acute type A aortic dissection (AAAD) poses a significant threat, with post-operative AKI being a closely related concern.
  • Limited data exist on AKI incidence using the latest Kidney Disease: Improving Global Outcomes (KDIGO) criteria and in-hospital mortality in AAAD patients.

Purpose of the Study:

  • To determine the incidence of AKI, defined by KDIGO criteria, in patients undergoing surgical treatment for AAAD.
  • To identify risk factors associated with the occurrence of AKI in this patient population.
  • To analyze risk factors contributing to in-hospital mortality among AAAD patients who develop AKI.

Main Methods:

  • Retrospective review of 335 patients who underwent surgical treatment for AAAD between March 2009 and June 2016.
  • Screening for AKI status and analysis of potential risk factors for AKI and in-hospital mortality.
  • Statistical analysis including independent-sample t-tests, Chi-square tests, and logistic regression to identify significant risk factors.

Main Results:

  • AKI incidence was 71.94% among AAAD patients, with stages 1, 2, and 3 occurring in 35.26%, 31.95%, and 32.78%, respectively.
  • In-hospital mortality rate was 21.16%.
  • Independent risk factors for AKI included higher BMI, chronic kidney disease, chronic liver disease, longer cardiopulmonary bypass duration, red blood cell transfusion, and hypoproteinemia. Mortality risk factors included AKI stage, deep hypothermic circulatory arrest, lactic acidosis, and need for continuous renal replacement therapy.

Conclusions:

  • AKI is a prevalent complication in surgically treated AAAD patients, significantly elevating mortality risk.
  • Identifying and mitigating risk factors for AKI are essential for improving post-operative outcomes in AAAD patients.
  • Further research and clinical attention are warranted to prevent AKI and manage its consequences in this high-risk group.

Keywords:
acute kidney injury (AKI)acute type A aortic dissection (AAAD)in-hospital mortalitykidney disease: improving global outcomes (KDIGO) criteriarisk factor

More Related Videos

Novel and Innovative Hybrid Technique for Type A Aortic Dissection06:26

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

661
Use of a Hanging-weight System for Isolated Renal Artery Occlusion07:54

Use of a Hanging-weight System for Isolated Renal Artery Occlusion

Published on: July 19, 2011

16.3K

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
161
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
624
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
331
Aneurysm IV: Nursing Management01:22

Aneurysm IV: Nursing Management

Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
238
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
591
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
132