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Published on: April 26, 2024
Role of tumor microenvironment in the efficacy of BCG therapy
Omar M Ibrahim1, Ravindra K Pandey2, Gurkamal Chatta3
1Department of Medicine, Division of Translational Research, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Abstract:
Despite its significant overall efficacy, BCG fails to benefit a substantial proportion of bladder cancer (BlCa) patients. Here, we review recent data highlighting the role of tumor microenvironment (TME) in limiting antitumoral activity of BCG treatment and emerging opportunities to target TME to enhance the overall outcomes in BCG-treated BlCa patients.
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