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In vitro Inhibition of Clinical Isolates of Otitis Media Pathogens by the Probiotic Streptococcus salivarius BLIS K12

Tzu Yu Chen1, John D F Hale2, John R Tagg2

  • 1Department of Otolaryngology, Head and Neck Surgery, Christchurch Public Hospital, Christchurch, New Zealand. tychen87@gmail.com.

Probiotics and Antimicrobial Proteins
|November 12, 2020
PubMed

Insights

New research shows Streptococcus salivarius BLIS K12 can inhibit common otitis media pathogens. This finding offers potential for novel strategies against childhood ear infections and antibiotic resistance.

Area of Science:

  • Microbiology
  • Pediatric Infectious Diseases
  • Bacteriology

Background:

  • Otitis media is a frequent childhood infection often treated with antibiotics.
  • Rising antibiotic resistance necessitates alternative prevention and treatment strategies for otitis media.

Purpose of the Study:

  • To evaluate the in vitro inhibitory effects of Streptococcus salivarius BLIS K12 against otitis media pathogens.
  • To explore the potential of S. salivarius BLIS K12 as a novel therapeutic agent.

Main Methods:

  • The study utilized the deferred antagonism test to assess the bacteriocin activity of S. salivarius BLIS K12.
  • In vitro inhibition of pathogenic isolates commonly associated with otitis media was measured.

Main Results:

  • Streptococcus salivarius BLIS K12 demonstrated inhibitory activity against 48% of tested otitis media pathogenic isolates.
  • Significant growth inhibition was observed for several key pathogens.

Conclusions:

  • S. salivarius BLIS K12 exhibits in vitro efficacy against prevalent otitis media pathogens.
  • These findings support further investigation into S. salivarius BLIS K12 for otitis media management and combating antibiotic resistance.
Keywords:
In vitro inhibitionOtitis mediaOtitis media pathogensProbioticsRecurrent otitis mediaS. salivarius BLIS K12

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