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Association of HLA-B22 serotype with SARS-CoV-2 susceptibility in Hong Kong Chinese patients

Yuk-Lin Yung1, Chi-Keung Cheng1, Hoi-Yun Chan1

  • 1Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.

HLA
|November 12, 2020
PubMed

Insights

The B22 serotype of the Human Leukocyte Antigen B (HLA-B) gene is significantly associated with increased susceptibility to SARS-CoV-2 infection. This finding offers insights into COVID-19 pathogenesis and prevention strategies.

Area of Science:

  • Immunogenetics
  • Virology
  • Epidemiology

Background:

  • COVID-19, caused by SARS-CoV-2, is a global pandemic with significant health and economic impacts.
  • The Human Leukocyte Antigen (HLA) system plays a crucial role in antiviral immunity.
  • Emerging evidence suggests HLA-B's involvement in COVID-19 susceptibility.

Purpose of the Study:

  • To investigate the association between HLA-B genotypes and SARS-CoV-2 infection in a Chinese population.
  • To identify specific HLA-B serotypes linked to COVID-19 susceptibility.

Main Methods:

  • Genotyping of HLA-B alleles in 190 unrelated Chinese patients diagnosed with COVID-19.
  • Statistical analysis to determine the association between HLA-B serotypes and SARS-CoV-2 infection.

Main Results:

  • A significant positive association was found between the HLA-B22 serotype and SARS-CoV-2 infection (p = 0.002).
  • The association remained significant after Bonferroni correction (p = 0.032).
  • The B22 serotype has a known link to susceptibility to other viral infections.

Conclusions:

  • The HLA-B22 serotype is a potential genetic marker for SARS-CoV-2 infection susceptibility.
  • Findings contribute to understanding SARS-CoV-2 pathogenesis and may inform vaccine development.
  • Results can guide improved infection prevention and control measures.

Keywords:
COVID-19ChineseHLASARS-CoV-2coronavirus

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