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Updated: Nov 30, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Ligand-Controlled Regioselective Pd-Catalyzed Diamination of Alkenes
Xiaojian Liu1, Chuanqi Hou2, Yiyuan Peng1
1Key Laboratory of Functional Small Organic Molecules, Ministry of Education, Jiangxi Province's Key Laboratory of Green Chemistry, Jiangxi Normal University, Nanchang 330022, China.
Abstract:
A ligand-controlled system has been disclosed for the regioselective palladium-catalyzed diamination of unactivated alkenes, which provides an easy access to a variety of amino-functionalized piperidines and pyrrolidines. The steric hindrance of ligands controlled the regioselectivtities of products. 6-Endo diamination occurred with less sterically hindered quinox ligand to afford 3-aminopiperidines, while 5-exo diamination occurred with sterically bulky pyox ligand to give amino-substituted pyrrolidines.
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