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Predictors of inflammatory activity in treatment-naive hepatitis B e-antigen-negative patients with chronic hepatitis

Jianhua Hu1, Yong Wang2, Gongying Jiang2

  • 1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

The Journal of International Medical Research
|November 12, 2020
PubMed

Insights

Total triiodothyronine (TT3) and hepatitis B virus (HBV) DNA levels can identify moderate liver inflammation in HBeAg-negative CHB patients. This may reduce the need for liver biopsies and guide treatment decisions for chronic hepatitis B.

Area of Science:

  • Hepatology
  • Virology
  • Biomarker Discovery

Background:

  • Accurate staging of liver inflammatory activity is crucial for managing chronic hepatitis B virus (CHB) infection.
  • Hepatitis B e-antigen (HBeAg)-negative CHB patients often require careful monitoring to determine the need for antiviral therapy.

Purpose of the Study:

  • To identify practical clinical biomarkers for detecting moderate inflammatory activity in treatment-naïve, HBeAg-negative CHB patients.
  • To evaluate the diagnostic accuracy of potential biomarkers in predicting significant liver inflammation.

Main Methods:

  • Retrospective analysis of 106 treatment-naïve, HBeAg-negative CHB patients who underwent liver biopsy.
  • Binary logistic regression analysis to identify predictors of moderate inflammatory activity (METAVIR score ≥A2).
  • Assessment of diagnostic accuracy using the area under the receiver operator characteristic curve (AUROCC).

Main Results:

  • 30.2% of enrolled patients exhibited moderate to severe liver inflammation (METAVIR score ≥A2).
  • Total triiodothyronine (TT3) and hepatitis B virus (HBV) DNA levels were significant predictors of moderate inflammatory activity.
  • The AUROCC for HBV DNA (0.797) was higher than for TT3 (0.651), with optimal cut-off values identified.

Conclusions:

  • A substantial proportion of HBeAg-negative CHB patients may require antiviral treatment based on biopsy findings.
  • TT3 and HBV DNA levels serve as valuable biomarkers to identify patients with moderate liver inflammation.
  • These biomarkers have the potential to reduce the reliance on liver biopsies and improve treatment guidance for CHB patients.
Abstract

Keywords:
Chronic hepatitis BHBeAg-negativeinflammatory activitynoninvasive biomarkersthyroid hormonetotal triiodothyronine

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