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Thiazide and thiazide-like diuretics in nephrolithiasis
Tamara da Silva Cunha1,2, Samirah Abreu Gomes3, Ita Pfeferman Heilberg1
1Universidade Federal de São Paulo, Escola Paulista de Medicina, Disciplina de Nefrologia, São Paulo, Brasil.
Abstract:
Thiazide and thiazide-like diuretics are widely used for the management of hypercalciuria among stone-forming patients. Although the effects of different thiazides should be relatively similar in terms of prevention of stone recurrence, their potency and side effects may differ. However, there is scarce data concerning the metabolic and bone effects of these agents among recurrent nephrolithiasis patients with hypercalciuria. The aim of this update article was to compare our experience in the use of thiazide and thiazide- like diuretics with that of the current literature, concerning their anticalciuric properties and consequent reduction of recurrent stone formation. Their impact on bone mass and potential side effects were also discussed.
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