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Morphometric evaluation of cerebellar structures in late monocular blindness
1Department of Radiology, Alaaddin Keykubat University Alanya Education and Research Hospital, Antalya, 07400, Turkey.
International Ophthalmology
|November 12, 2020
Summary
Late-onset monocular blindness (LMB) is associated with significant cerebellar anatomical changes. Individuals with LMB showed altered cerebellar lobule volumes and reduced cortical thickness compared to controls.
Area of Science:
- Neuroscience
- Neuroimaging
- Human Anatomy
Background:
- Limited research exists on structural and functional brain changes in individuals with monocular blindness.
- Investigating cerebellar alterations in late-onset monocular blindness (LMB) is crucial for understanding visual pathway adaptations.
Purpose of the Study:
- To segmentally investigate cerebellar structures in individuals with late-onset monocular blindness (LMB).
- To compare cerebellar volumetric and cortical thickness metrics between LMB patients and healthy controls.
Main Methods:
- Utilized Voxel-based volumetric analysis on 3D T1 FSPGR MRI sequence images.
- Calculated segmental volumetric values, cortical thickness, gray matter volumes, and percentage ratios of cerebellar lobules.
- Employed the volBrain CERES 1.0 website for data analysis.
Main Results:
- Eleven subjects with LMB and 11 healthy controls were studied.
- The LMB group exhibited higher cerebellar lobule crus II volume and cerebellar lobule VIIB/VIIIA volume/percentage.
- Reduced cerebellar cortical thickness and cerebellar lobule VI gray matter volume were observed in the LMB group.
Conclusions:
- Cerebellar lobule VIIB/VIIIA volume/total percent ratio, cerebellar cortical thickness, and cerebellar gray matter volume differ between individuals with LMB and controls.
- This study is the first to report specific cerebellar anatomical changes in patients with late-onset monocular blindness.
