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The Diagnostic Value of Multi-Index Combined Detection in Patients with COVID-19
Insights
Combined laboratory tests accurately diagnose COVID-19 and predict disease severity. Key indicators like lymphocytes and C-reactive protein levels help distinguish between severe and non-severe cases, improving diagnostic accuracy.
Area of Science:
- Clinical diagnostics
- Infectious disease research
- Biomarker discovery
Background:
- New coronavirus disease 2019 (COVID-19) presents diagnostic challenges.
- Understanding laboratory markers is crucial for effective patient management.
Purpose of the Study:
- To evaluate the diagnostic value of multi-index combined detection for COVID-19.
- To assess the efficacy of laboratory markers in predicting COVID-19 severity.
Main Methods:
- Compared laboratory characteristics of 63 COVID-19 patients (28 severe, 35 non-severe) with 50 healthy controls.
- Analyzed levels of lymphocytes, red blood cells, hemoglobin, platelets, total protein, albumin, monocytes, AST, GGT, and CRP.
Main Results:
- COVID-19 patients showed altered levels of LYM, RBC, HGB, PLT, TP, ALB, MON, AST, GGT, and CRP compared to healthy individuals.
- Severe cases exhibited significantly higher MON and CRP, and lower LYM and ALB than non-severe cases.
- Combined detection of ten laboratory indexes achieved 97.7% sensitivity and 91.7% specificity for COVID-19 diagnosis.
Conclusions:
- A panel of laboratory indexes (LYM, MON, RBC, HGB, PLT, TP, ALB, AST, GGT, CRP) can effectively diagnose COVID-19.
- Specific indicators (LYM, MON, ALB, CRP) show potential for predicting COVID-19 severity.
- Combined laboratory testing offers a more accurate approach for COVID-19 diagnosis and severity prediction.
Background:
To investigate the clinical value of multi-index combined detection in the diagnosis of new coronavirus disease 2019 (COVID-19).
Methods:
A total of 63 laboratory confirmed patients treated in our hospital were selected as the COVID-19 group, including 28 severe patients and 35 non-severe patients. Another 50 healthy subjects undergoing physical examination simultaneously were selected as the healthy group. Here we performed a study on the laboratory characteristics and explored their efficacy for diagnosis of the disease.
Results:
Compared with healthy people, the abnormal indicators of patients with COVID-19 are low levels of lymphocytes (LYM), red blood cells (RBC), hemoglobin (HGB), platelets (PLT), total protein (TP), and albumin (ALB), and high levels of monocytes (MON), aspartate aminotransferase (AST), gamma glutamyl transpeptidase (GGT), and C-reactive protein (CRP). The level of MON and CRP in severe patients were significantly increased compared with non-severe pneumonia patients, and indicators such as LYM and ALB were significantly reduced (p < 0.05). The sensitivity and specificity of the combined detection of LYM, MON, RBC, HGB, PLT, TP, ALB, AST, GGT, and CRP was 97.7% and 91.7%, which was higher than the single item (p < 0.05). The sensitivity and specificity of combined detection of LYM, MON, ALB, and CRP to predict the severity of COVID-19 were 96.4% and 73.0%, which were higher than those of separate detections (p < 0.05).
Conclusions:
The index of LYM, MON, RBC, HGB, PLT, TP, ALB, AST, GGT, and CRP can be used for the diagnosis of new COVID-19, and the indicators of LYM, MON, ALB, and CRP may be predictors of severe pneumonia. The combined detection of the laboratory indexes can diagnose COVID-19 and predict the severity more effectively and accurately.
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