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Relationship Between Serum IGF-1 and BMI Differs by Age
Rehab A Sherlala1, Candace M Kammerer1, Allison L Kuipers2
1Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pennsylvania.
Summary
The link between insulin-like growth factor 1 (IGF-1) and body mass index (BMI) changes with age. Younger adults show a negative correlation, while older adults exhibit a positive correlation, explaining previous conflicting findings.
Area of Science:
- Gerontology
- Endocrinology
- Biostatistics
Background:
- Serum insulin-like growth factor 1 (IGF-1) and body mass index (BMI) are linked to age-related disease susceptibility.
- Previous studies report conflicting correlations between IGF-1 and BMI, possibly due to wide age range variations.
Purpose of the Study:
- To investigate the relationship between IGF-1 and BMI across different age groups.
- To clarify inconsistencies in prior research regarding the IGF-1 and BMI correlation.
Main Methods:
- Utilized data from 4241 participants (aged 24-110) in the Long Life Family Study.
- Employed regression analysis stratified by age quartiles.
- Confirmed findings with data from the third National Health and Nutritional Examination Survey.
Main Results:
- The correlation between IGF-1 and BMI varied significantly by age quartile.
- A negative correlation was observed in the youngest quartile (20-58 years), becoming non-significant in middle age groups.
- A significant positive correlation emerged in the oldest quartile (87-110 years).
- This age-related pattern was consistent across sexes and in a separate population survey.
Conclusions:
- The age-dependent relationship between IGF-1 and BMI helps explain conflicting previous findings.
- Further research is warranted to elucidate the underlying biological mechanisms driving this age-related pattern.
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