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Relationship Between Serum IGF-1 and BMI Differs by Age.

Rehab A Sherlala1, Candace M Kammerer1, Allison L Kuipers2

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The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|November 12, 2020
PubMed
Summary

The link between insulin-like growth factor 1 (IGF-1) and body mass index (BMI) changes with age. Younger adults show a negative correlation, while older adults exhibit a positive correlation, explaining previous conflicting findings.

Keywords:
Age-related diseasesAge-related patternRegression analysis

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Area of Science:

  • Gerontology
  • Endocrinology
  • Biostatistics

Background:

  • Serum insulin-like growth factor 1 (IGF-1) and body mass index (BMI) are linked to age-related disease susceptibility.
  • Previous studies report conflicting correlations between IGF-1 and BMI, possibly due to wide age range variations.

Purpose of the Study:

  • To investigate the relationship between IGF-1 and BMI across different age groups.
  • To clarify inconsistencies in prior research regarding the IGF-1 and BMI correlation.

Main Methods:

  • Utilized data from 4241 participants (aged 24-110) in the Long Life Family Study.
  • Employed regression analysis stratified by age quartiles.
  • Confirmed findings with data from the third National Health and Nutritional Examination Survey.

Main Results:

  • The correlation between IGF-1 and BMI varied significantly by age quartile.
  • A negative correlation was observed in the youngest quartile (20-58 years), becoming non-significant in middle age groups.
  • A significant positive correlation emerged in the oldest quartile (87-110 years).
  • This age-related pattern was consistent across sexes and in a separate population survey.

Conclusions:

  • The age-dependent relationship between IGF-1 and BMI helps explain conflicting previous findings.
  • Further research is warranted to elucidate the underlying biological mechanisms driving this age-related pattern.