Related Experiment Video

Updated: Nov 30, 2025

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

25.9K

Long noncoding RNAs: Potential therapeutic targets in cardiocerebrovascular diseases

Hao Zhang1, Bo Liu1, Xingjuan Shi2

  • 1Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China.

Pharmacology & Therapeutics
|November 12, 2020
PubMed

Insights

Long noncoding RNAs (lncRNAs) are key regulators in cardiocerebrovascular diseases. Understanding lncRNA roles offers new diagnostic and therapeutic strategies for these complex conditions.

Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Genetics

Background:

  • Cardiocerebrovascular diseases encompass cardiovascular and cerebrovascular conditions with complex, poorly understood mechanisms.
  • Current treatments for these diseases are limited due to their intricate nature.
  • Precision medicine is driving research into novel molecular players, such as long noncoding RNAs (lncRNAs).

Purpose of the Study:

  • To review the roles and mechanisms of long noncoding RNAs (lncRNAs) in cardiocerebrovascular diseases.
  • To explore the clinical utility of lncRNAs as biomarkers for diagnosis and prognosis.
  • To provide a new perspective on the diagnosis and treatment of cardiocerebrovascular diseases.

Main Methods:

  • Literature review focusing on studies investigating lncRNAs in cardiocerebrovascular diseases.
  • Analysis of the regulatory functions of lncRNAs at epigenetic, transcriptional, and post-transcriptional levels.
  • Examination of the association between abnormal lncRNA expression and disease progression.

Main Results:

  • Long noncoding RNAs (lncRNAs) are implicated in the pathogenesis of cardiocerebrovascular diseases.
  • Abnormal lncRNA expression correlates with disease occurrence and advancement.
  • LncRNAs modulate gene expression and disease progression through specific mRNA binding.

Conclusions:

  • LncRNAs play critical roles in the development and progression of cardiocerebrovascular diseases.
  • LncRNAs demonstrate potential as biomarkers for diagnosing and predicting outcomes.
  • Targeting lncRNAs may offer novel therapeutic avenues for cardiocerebrovascular diseases.

Keywords:
Cardiocerebrovascular diseaseDiagnosis and prognosisLong noncoding RNA

More Related Videos

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.2K
Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

894

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.5K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.2K
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
8.4K
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
71.3K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
17.8K
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.9K