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Intraspinal stimulation with a silicon-based 3D chronic microelectrode array for bladder voiding in cats.

Victor Pikov1, Douglas B McCreery2, Martin Han3,4

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|November 12, 2020
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Summary
This summary is machine-generated.

Researchers developed a 3D intraspinal microstimulation array to restore bladder control in spinal cord injury (SCI) models. This technology shows promise for improving bladder voiding after SCI.

Keywords:
bladder dysfunctionmicrostimulationsilicon-based microelectrode arrayspinal cord injury

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Regenerative Medicine

Background:

  • Bladder dysfunction is a major challenge for individuals with spinal cord injury (SCI).
  • Current management like intermittent catheterization lacks volitional control and has side effects.
  • Electrical microstimulation of the spinal cord is being explored to restore bladder function.

Purpose of the Study:

  • To develop and evaluate a novel 3D intraspinal microstimulation array for precise bladder control.
  • To assess the array's ability to restore volitional micturition in a feline model of SCI.
  • To investigate the long-term implantation feasibility and effectiveness of the technology.

Main Methods:

  • Fabrication of a mechanically robust, 3D intraspinal multisite silicon array with custom tip geometry.
  • Long-term implantation (up to 6 months) in spinally intact feline models targeting the S2 sacral cord.
  • Evaluation of micturition-related responses to electrical stimulation and assessment after spinal cord transection (SCT).

Main Results:

  • Approximately one-third of stimulated sites in the target area elicited micturition responses.
  • Bladder responsiveness to stimulation increased post-SCT, suggesting spinal circuitry adaptation.
  • The 3D array demonstrated chronic implantability and a beneficial effect on bladder voiding.

Conclusions:

  • 3D intraspinal microstimulation arrays offer a potential solution for bladder voiding dysfunction after SCI.
  • The technology shows promise in both intact and transected spinal cord models.
  • Further research is needed to confirm long-term safety and efficacy before human trials.