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Refractive growth variability in the Infant Aphakia Treatment Study

Scott K McClatchey1, Thaddeus S McClatchey, George Cotsonis

  • 1From the Department of Ophthalmology, Naval Medical Center, San Diego, California (S.K. McClatchey, T.S. McClatchey); Uniformed Services University of Health Sciences, Bethesda, Maryland (S.K. McClatchey); School of Medicine, California University of Science and Medicine, San Bernardino, California (T.S. McClatchey); Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia (Cotsonis, Nizam); Department of Ophthalmology, School of Medicine, Stanford University, Palo Alto, California (Lambert).

Journal of Cataract and Refractive Surgery
|November 12, 2020
PubMed

Insights

Children’s cataract surgery outcomes vary. This study found the rate of refractive growth (RRG3) in operated eyes had significantly more variance than normal eyes, impacting refractive prediction.

Area of Science:

  • Ophthalmology
  • Pediatric ophthalmology
  • Refractive error research

Background:

  • Predicting refractive outcomes after pediatric cataract surgery is challenging due to variability in refractive growth.
  • The Infant Aphakia Treatment Study provides longitudinal data crucial for understanding these outcomes.

Purpose of the Study:

  • To compare the rate of refractive growth (RRG3) in aphakic and pseudophakic eyes with their fellow normal eyes.
  • To analyze the variance in RRG3 in children following unilateral cataract surgery.

Main Methods:

  • A randomized clinical trial involving infants undergoing unilateral cataract extraction.
  • Biometric data (axial length, keratometry) were collected at surgery and 10 years of age.
  • Variance in RRG3 was compared between normal, aphakic, and pseudophakic eyes using statistical analysis.

Main Results:

  • Longitudinal data from 103 patients were analyzed.
  • The variance in RRG3 was significantly higher in operated eyes (aphakic and pseudophakic) compared to normal eyes (P < .0001).
  • Variance in axial length growth also differed significantly between operated and normal eyes (P < .0001).

Conclusions:

  • The standard deviation of RRG3 in normal eyes was half that observed in eyes after cataract surgery.
  • Increased variance in refractive growth in operated eyes presents a significant challenge for refractive prediction in pediatric aphakia and pseudophakia.
Abstract

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