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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Gut microbiome and multiple sclerosis: New insights and perspective
Mohammad Esmaeil Amini1, Navid Shomali2, Arash Bakhshi3
1Department of Microbiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran; Student Research Committee, Guilan University of Medical Sciences, Rasht, Iran.
International Immunopharmacology
|November 13, 2020
Summary
The gut microbiota influences multiple sclerosis (MS) pathogenesis. Modifying the intestinal microbiome offers a promising therapeutic strategy for managing MS and its associated central nervous system inflammation.
Area of Science:
- Neuroimmunology
- Microbiome Research
- Gastroenterology
Background:
- The human gut microbiota significantly impacts various disorders, including multiple sclerosis (MS).
- MS is a central nervous system inflammatory disease with complex pathogenesis involving genetic and external factors.
- Emerging evidence suggests a crucial role for the intestinal microbiome in MS development.
Purpose of the Study:
- To review the characteristics of intestinal microbiota in relation to MS.
- To explore the gut-brain axis and factors influencing the gut microbiome.
- To discuss microbiome modification strategies for potential MS treatment.
Main Methods:
- Literature review on gut microbiota and MS.
- Analysis of studies on experimental autoimmune encephalomyelitis (EAE) as an MS model.
- Discussion of factors affecting intestinal microbial composition.
Main Results:
- The gut microbiome composition is altered in individuals with MS.
- The gut-brain axis facilitates communication between the intestine and the central nervous system.
- Various factors can modify the intestinal microbiome.
Conclusions:
- Intestinal microbiota plays a key role in MS pathogenesis.
- Modifying the gut microbiome presents a potential therapeutic avenue for MS.
- Further research into microbiome-targeted therapies for MS is warranted.
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