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Systematic expression analysis of EAF family reveals the importance of EAF2 in melanoma

Wei Han1, Guo-Liang Shen1

  • 1Department of Burn and Plastic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215000, PR China; Department of Surgery, Soochow University, Suzhou 215000, PR China.

International Immunopharmacology
|November 13, 2020
PubMed
Abstract

Insights

Elevated EAF2 expression is linked to better outcomes in skin cutaneous melanoma (SKCM). This study highlights EAF2 as a promising biomarker for SKCM diagnosis and prognosis, potentially aiding immune response understanding.

Area of Science:

  • Oncology
  • Dermatology
  • Immunology

Background:

  • Skin cutaneous melanoma (SKCM) is a leading cause of cancer death.
  • The role of EAF2 in SKCM has not been well-established.
  • EAF2 family members are implicated in various cancers.

Purpose of the Study:

  • To analyze EAF2 expression in SKCM.
  • To investigate the diagnostic and prognostic value of EAF2 in melanoma.
  • To explore the association between EAF2 and immune infiltration in SKCM.

Main Methods:

  • Bioinformatics analysis of EAF family expression.
  • Prognostic value assessment using survival analysis and ROC curves.
  • Correlation analysis of EAF2 expression with immune cell infiltration and co-expression.

Main Results:

  • EAF2 expression is upregulated in SKCM at both transcriptional and proteomic levels.
  • EAF2 demonstrates significant diagnostic and prognostic capabilities.
  • EAF2 expression correlates with immune cell infiltration (B cells, T cells, neutrophils, macrophages, dendritic cells) and CD19.

Conclusions:

  • This study is the first to demonstrate that elevated EAF2 expression correlates with tumor progression and improved prognosis in SKCM.
  • EAF2 may serve as a potential biomarker for diagnosing SKCM and predicting patient prognosis.
  • EAF2's role in SKCM suggests potential involvement in the immune response.
Keywords:
CD19EAF2ImmuneMelanomaPrognosis

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