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High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing
Published on: January 22, 2019
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Experimental Systems for Measuring HIV Latency and Reactivation.
Koh Fujinaga1, Daniele C Cary2
1Division of Rheumatology, Department of Medicine, School of Medicine, University of California, San Francisco, CA 94143-0703, USA.
Viruses
|November 13, 2020
Summary
Eliminating latent HIV reservoirs is key to an HIV/AIDS cure. This review compares in vitro experimental systems used to study HIV latency and reactivation, crucial for developing new therapies.
Area of Science:
- Virology
- Immunology
- Infectious Diseases
Background:
- Latent HIV reservoirs prevent a cure for HIV/AIDS, producing infectious virus upon therapy cessation.
- Antiretroviral therapy controls but does not eradicate HIV, highlighting the need to target latent reservoirs.
Purpose of the Study:
- To review and compare experimental systems used for studying HIV latency in vitro.
- To understand mechanisms regulating HIV latency and reactivation.
Main Methods:
- Comparison of various in vitro experimental models for HIV latency.
- Analysis of systems used to study HIV reactivation and elimination of infected cells.
Main Results:
- Multiple experimental systems exist to model HIV latency in vitro.
- Each system offers insights into HIV latency mechanisms but has limitations.
Conclusions:
- Understanding HIV latency requires diverse experimental models.
- Developing effective HIV cure strategies necessitates targeting latent reservoirs.
