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Updated: Nov 30, 2025
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
13.5K
Curcumin against Prostate Cancer: Current Evidence
Deborah Termini1, Danja J Den Hartogh1,2, Alina Jaglanian1
1Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.
Biomolecules
|November 13, 2020
Summary
Curcumin, a compound from turmeric, shows potential in fighting prostate cancer by inhibiting cell growth and promoting cell death. This review explores its anticancer effects based on existing research.
Area of Science:
- Oncology
- Pharmacology
- Natural Products Chemistry
Background:
- Cancer involves uncontrolled cell growth and survival due to genetic mutations.
- Plant-derived compounds are a historical source of medicinal treatments, including chemotherapy.
- Curcumin, a polyphenol from turmeric, exhibits anticancer properties like antiproliferative and proapoptotic effects.
Purpose of the Study:
- To review and summarize existing in vitro and in vivo research on curcumin's effects in prostate cancer models.
- To consolidate evidence on curcumin's potential as an anticancer agent for prostate cancer.
Main Methods:
- Comprehensive literature search for studies investigating curcumin and prostate cancer.
- Inclusion of both laboratory (in vitro) and animal (in vivo) research findings.
- Synthesis of data regarding curcumin's impact on prostate cancer cell behavior.
Main Results:
- Curcumin demonstrates antiproliferative activity, reducing prostate cancer cell growth.
- Curcumin induces apoptosis (programmed cell death) in prostate cancer cells.
- Evidence from various studies supports curcumin's therapeutic potential in prostate cancer.
Conclusions:
- Curcumin exhibits significant anticancer effects against prostate cancer in preclinical studies.
- Further research into curcumin's mechanisms and clinical efficacy is warranted.
- Curcumin represents a promising natural compound for prostate cancer therapeutic strategies.
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