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Conducting Respiratory Oscillometry in an Outpatient Setting
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Oscillometry as a Predictor of Exercise Tolerance in COPD.

Akito Yamamoto1, Toshihiro Shirai1, Keita Hirai2

  • 1Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan.

COPD
|November 13, 2020
PubMed
Summary

Oscillometry, specifically inspiratory R5, can predict reduced exercise tolerance in COPD patients. This finding may help identify individuals needing interventions to improve their 6-minute walking distance.

Keywords:
Walk testchronic obstructiveoscillometrypulmonary diseaserespiratory function tests

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Area of Science:

  • Respiratory Medicine
  • Pulmonary Function Testing
  • Exercise Physiology

Background:

  • Exercise intolerance is a key issue for COPD patients.
  • The forced oscillation technique (FOT) is a non-invasive method to assess respiratory mechanics.
  • Its utility in predicting exercise capacity in COPD remains unclear.

Purpose of the Study:

  • To investigate if oscillometry parameters can predict a 6-minute walking distance (6MWD) below 350 meters in COPD patients.
  • To assess the predictive value of FOT in identifying individuals with low exercise tolerance.

Main Methods:

  • A prospective observational study included 57 COPD patients.
  • Measurements included the modified Medical Research Council (mMRC) dyspnea scale, COPD Assessment Test (CAT), spirometry, oscillometry, and the 6-minute walk test (6MWT).
  • Multivariate regression and ROC curve analyses were used to identify predictors of 6MWD <350m.

Main Results:

  • 14 (24.6%) patients had a 6MWD <350m.
  • Significant differences between groups (6MWD ≥350m vs <350m) were observed in mMRC, GOLD stage, CAT score, FEV1, IC, 6MWD, SpO2, Borg scale, respiratory resistance (Rrs), and reactance (Xrs).
  • Inspiratory R5 (respiratory resistance at 5 Hz) independently predicted 6MWD <350m (OR 6.01). CAT score also predicted low exercise tolerance.

Conclusions:

  • The oscillatory parameter, inspiratory R5, is a significant predictor of low exercise tolerance in COPD subjects.
  • Combining CAT scores and R5 demonstrated a high area under the curve (0.85) for predicting reduced exercise capacity.
  • Oscillometry offers a valuable tool for assessing exercise tolerance in COPD management.