Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Migration01:09

Cell Migration

17.9K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
17.9K
Cell Migration01:19

Cell Migration

6.0K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Matrix composition modulates cancer cell phenotypes and secretions in a blood-brain barrier organ-on-a-chip model: Comparison of collagen and hyaluronic acid.

Biomaterials·2026
Same author

NCCN Guidelines® Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate, Version 2.2026.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

Precision Oncology for High-Grade Gliomas: A Tumor Organoid Model for Adjuvant Treatment Selection.

Bioengineering (Basel, Switzerland)·2025
Same author

Interplay between malic enzyme 2, de novo serine synthesis, and the malate-aspartate shuttle drives metabolic adaptation in triple-negative breast cancer.

Cancer & metabolism·2025
Same author

Transcriptional profiling clarifies a program of enzalutamide extreme non-response in lethal prostate cancer.

NPJ precision oncology·2025
Same author

PROX1 is an early driver of lineage plasticity in prostate cancer.

The Journal of clinical investigation·2025

Related Experiment Video

Updated: Nov 30, 2025

Radial Mobility and Cytotoxic Function of Retroviral Replicating Vector Transduced, Non-adherent Alloresponsive T Lymphocytes
10:01

Radial Mobility and Cytotoxic Function of Retroviral Replicating Vector Transduced, Non-adherent Alloresponsive T Lymphocytes

Published on: February 11, 2015

8.0K

Development of an Enhanced-Throughput Radial Cell Migration Device.

C Ryan Oliver1,2, Andrew C Little1, Trisha M Westerhof1

  • 1Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

SLAS Technology
|November 13, 2020
PubMed
Summary

We developed a new, reliable method to measure cell migration in all directions without chemical signals. This high-throughput system aids in screening cancer drug responses and genetic alterations.

Keywords:
HTSautomated biologycell seedinghigh-content imaginghigh-throughput screeningmigration assay

More Related Videos

Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

12.3K
A Device for Performing Cell Migration/Wound Healing in a 96-Well Plate
05:46

A Device for Performing Cell Migration/Wound Healing in a 96-Well Plate

Published on: March 7, 2017

11.0K

Related Experiment Videos

Last Updated: Nov 30, 2025

Radial Mobility and Cytotoxic Function of Retroviral Replicating Vector Transduced, Non-adherent Alloresponsive T Lymphocytes
10:01

Radial Mobility and Cytotoxic Function of Retroviral Replicating Vector Transduced, Non-adherent Alloresponsive T Lymphocytes

Published on: February 11, 2015

8.0K
Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

12.3K
A Device for Performing Cell Migration/Wound Healing in a 96-Well Plate
05:46

A Device for Performing Cell Migration/Wound Healing in a 96-Well Plate

Published on: March 7, 2017

11.0K

Area of Science:

  • Cell biology
  • Biotechnology
  • Biomedical engineering

Background:

  • Assessing cell migration is crucial for understanding biological processes and disease progression.
  • Existing methods for measuring cell migration, such as scratch wound assays, have limitations in throughput and unbiased measurement.
  • There is a need for sensitive, high-throughput methods to evaluate cell migration in response to various stimuli.

Purpose of the Study:

  • To develop and validate a novel, reliable, and sensitive method for observing and measuring unrestricted radial cell migration.
  • To adapt this method for high-throughput automated imaging systems.
  • To enable phenotypic screening of cellular responses to therapeutic agents and genetic modifications.

Main Methods:

  • Combined a standard radial migration assay with injection-molded gaskets and a rigid fixture.
  • Adapted the device for use with high-throughput automated imaging systems.
  • Utilized low-cost, replaceable cell-wetted components and allowed for secondary placement of attractants and co-cultures.

Main Results:

  • Developed a highly reliable and sensitive method for observing and measuring radial cell migration.
  • The method is adaptable for high-throughput automated imaging, enabling efficient screening.
  • The device design allows for cost-effective component replacement and versatile experimental setups.

Conclusions:

  • The developed device provides a systematic, reliable, and rapid application for monitoring phenotypic responses.
  • This noninvasive, enhanced-throughput approach is orthogonal to other 2D cell migration assays.
  • The methodology offers a reliable way to survey unbiased cell migration in response to chemotherapeutic screens, genetic alterations, and other interventions.