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Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
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Current Updates in Transdermal Therapeutic Systems and Their Role in Neurological Disorders
Neelu Yadav1, Ashu Mittal1, Javed Ali2
1Department of Pharmaceutics, KIET School of Pharmacy (KIET Group of Institutions), Ghaziabad, Uttar Pradesh, India.
Current Protein & Peptide Science
|November 13, 2020
Summary
Transdermal therapeutic systems offer a non-invasive, effective approach for managing neuropathic pain and neurological disorders. These systems improve drug delivery, enhance patient compliance, and show promise for conditions like Alzheimer's disease.
Area of Science:
- Neurology
- Pharmacology
- Biomedical Engineering
Background:
- Transdermal drug delivery is crucial for treating neuropathic pain and chronic neurological disorders, especially in the elderly.
- This method offers sustained drug levels, bypasses first-pass metabolism, and improves bioavailability, reducing side effects and enhancing patient compliance.
- Conventional dosage forms present challenges for chronic neurological disorder management, making transdermal routes a viable alternative.
Purpose of the Study:
- To review recent technological advancements in transdermal therapeutic systems.
- To explore the applications of these systems in treating various neurological disorders.
- To highlight the potential of transdermal drug delivery for improved therapeutic outcomes.
Main Methods:
- Review of current literature on transdermal therapeutic systems and their applications in neurology.
- Focus on emerging technologies such as microneedles and ultrasound-based systems.
- Analysis of transdermal drug administration for conditions including Alzheimer's disease and neuropathic pain.
Main Results:
- Transdermal systems are effective for sustained drug delivery, improving treatment for neurological conditions.
- Specific technologies like microneedles and ultrasound show significant potential for enhanced drug penetration and efficacy.
- Transdermal administration for Alzheimer's disease demonstrates notable improvements in cognitive and global functioning.
Conclusions:
- Transdermal therapeutic systems represent a significant advancement in managing neurological disorders.
- Technological innovations are expanding the utility and effectiveness of transdermal drug delivery.
- Further research into these systems promises better therapeutic outcomes for patients with neurological conditions.
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