Related Experiment Video
Updated: Nov 30, 2025
07:46
In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer
Published on: August 17, 2010
34.2K
An Overview of Ovarian Cancer: Molecular Processes Involved and Development of Target-based Chemotherapeutics
Basheerulla Shaik1, Tabassum Zafar2, Krishnan Balasubramanian3
1Department of Applied Sciences, National Institute of Technical Teachers' Training & Research, Shamla Hills, Shanti Marg, Bhopal-462002, Madhya Pradesh, India.
Current Topics in Medicinal Chemistry
|November 13, 2020
Summary
Ovarian cancer remains a significant threat, with limited clinical progress despite advances in research. This review explores molecular processes and theoretical approaches for developing novel chemotherapeutics to combat drug resistance and recurrence.
Area of Science:
- Gynecologic Oncology
- Molecular Biology
- Chemotherapeutics
Background:
- Ovarian cancer is a leading cause of cancer death in women globally.
- Despite advances in genomics, proteomics, and radiomics, clinical translation for ovarian cancer treatment remains limited.
- Late-stage diagnosis due to asymptomatic progression is a major challenge.
Purpose of the Study:
- To provide an overview of current research on molecular processes in ovarian cancer development.
- To explore the potential of these molecular processes for developing novel chemotherapeutics.
- To discuss theoretical approaches applied in the development of ovarian cancer treatments.
Main Methods:
- Review of existing studies on ovarian cancer molecular pathways.
- Analysis of research on target-based drug development.
- Examination of theoretical approaches for chemotherapeutic development.
Main Results:
- Identification of key molecular processes implicated in ovarian cancer.
- Evaluation of the efficacy and limitations of current target-based drugs.
- Assessment of the success of theoretical approaches in guiding chemotherapeutic development.
Conclusions:
- Further research into molecular processes is crucial for advancing ovarian cancer treatment.
- Addressing drug resistance and recurrence requires innovative therapeutic strategies.
- Theoretical approaches offer promising avenues for future ovarian cancer drug discovery.
Related Concept Videos
02:57Targeted Cancer Therapies
8.2K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.2K
03:03mTOR Signaling and Cancer Progression
4.3K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.3K
02:18Cancer
52.6K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
52.6K
02:49Cancer Therapies
9.3K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.3K
02:56Treatment Resistant Cancers
3.5K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.5K
02:07Tumor Progression
7.0K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.0K