A nomogram for predicting overall survival in patients with Ewing sarcoma: a SEER-based study

Area of Science:

• Pediatric Oncology
• Cancer Prognostics
• Biostatistics

Background:

• Ewing sarcoma is a common pediatric bone tumor, often presenting with localized or metastatic disease.
• Accurate prognostic tools are crucial for managing patients with Ewing sarcoma.

Purpose of the Study:

• To construct and validate a nomogram for predicting 3- and 5-year overall survival (OS) in Ewing sarcoma patients.
• To identify independent prognostic factors for Ewing sarcoma.

Main Methods:

• Utilized data from the Surveillance, Epidemiology, and End Results (SEER) database (2010-2015).
• Performed univariate and multivariate Cox regression analyses to identify significant prognostic factors.
• Constructed a nomogram using independent variables and validated it with c-indexes and calibration curves.

Main Results:

• Identified age, N stage, and bone metastasis as independent predictors of OS.
• The developed nomogram demonstrated good predictive accuracy with c-indexes of 0.757 (training) and 0.697 (validation).
• Calibration curves indicated the nomogram's reliable prognostic performance.

Conclusions:

• The individualized nomogram shows significant potential for prognostic prediction in Ewing sarcoma.
• This tool can aid clinicians in providing personalized care and improving outcomes for pediatric patients.