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Cross-segment spinal plasma cell granuloma:a case report.

Renqin Lin1, Shenglin Wang1, Jianhua Lin1

  • 1Department of Orthopedic Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350005, P.R. China.

BMC Musculoskeletal Disorders
|November 13, 2020
PubMed
Summary
This summary is machine-generated.

This study reports the first case of spinal plasma cell granuloma (PCG) affecting multiple vertebrae. This rare condition presents as osteolytic lesions and requires surgical resection for diagnosis and treatment.

Keywords:
Case reportPlasma cell granulomaSurgeryThoracolumbar spine

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Area of Science:

  • Spinal oncology
  • Pathology
  • Rare diseases

Background:

  • Plasma cell granuloma (PCG) is a rare, non-neoplastic condition with an unclear etiology.
  • Spinal involvement by PCG, particularly cross-segmental lesions, has not been previously reported.
  • This case highlights a unique presentation of PCG in the thoracolumbar spine.

Observation:

  • A 32-year-old male presented with asymptomatic osteolytic lesions in the T12 and L1 vertebrae.
  • Radiological and laboratory findings excluded malignancy.
  • Initial biopsy was inconclusive, necessitating complete lesion excision.

Findings:

  • Pathological examination of the surgical specimen confirmed plasma cell infiltration, diagnosing spinal PCG.
  • This represents the first reported instance of cross-segment spinal PCG with osteolytic properties.
  • The diagnosis was established through exclusion and definitive surgical pathology.

Implications:

  • Spinal PCG should be considered in the differential diagnosis of osteolytic spinal lesions.
  • Surgical resection is crucial for both definitive diagnosis and therapeutic management of spinal PCG.
  • Further research into the etiology of PCG may improve diagnostic and treatment strategies.