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Updated: Nov 30, 2025

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
Published on: April 26, 2019
Advances and Pitfalls in the Diagnosis of Hirschsprung Disease
1Department of Pathology, University of Utah, Salt Lake City, UT, USA; Seattle Children's Hospital, University of Washington, OC.8.720 4800, Sand Point Way Northeast, Seattle, WA 98105, USA.
Abstract:
Surgical pathology for Hirschsprung disease (HSCR) occasionally is difficult, especially for those who encounter the disorder infrequently. This article reviews pathologic features of HSCR, considers various specimens the pathologist is required to evaluate, and discusses useful ancillary tests. Potential diagnostic pitfalls are highlighted, and helpful hints are provided to successfully navigate challenging situations. Finally, the article looks forward to new ancillary tests on the horizon and future topics for HSCR research.
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