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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
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Cytokines in oncolytic virotherapy
Jonathan G Pol1, Samuel T Workenhe2, Prathyusha Konda3
1Centre de Recherche des Cordeliers, Equipe 11 labellisée par la Ligue Nationale contre le Cancer, INSERM, Sorbonne Université, Université de Paris, Paris, France; Gustave Roussy Cancer Campus, Metabolomics and Cell Biology Platforms, Villejuif, France.
Cytokine & Growth Factor Reviews
|November 13, 2020
Summary
Oncolytic viruses transform tumors into immune-friendly zones. These viruses promote cancer cell death, attracting immune cells to fight tumors effectively through oncolytic virotherapy.
Area of Science:
- Immunology
- Virology
- Oncology
Background:
- Tumors create hostile environments, suppressing anti-cancer immune cells.
- Immune cells struggle to infiltrate tumors and eliminate cancer cells due to immunosuppressive factors.
Purpose of the Study:
- To review how oncolytic viruses reshape the tumor microenvironment.
- To identify key signaling molecules involved in oncolytic virotherapy's immune response.
Main Methods:
- Review of scientific literature on oncolytic viruses and tumor immunology.
- Analysis of signaling pathways and cellular interactions in the tumor microenvironment.
Main Results:
- Oncolytic viruses induce immunogenic cancer cell death.
- This process releases danger signals and antigens, attracting and activating immune cells.
- Key cytokines and chemokines orchestrate leukocyte activity against tumors.
Conclusions:
- Oncolytic virotherapy effectively reconditions the tumor microenvironment for anti-tumor immunity.
- It enhances immune cell infiltration and cytotoxic activity, offering a promising cancer treatment strategy.
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