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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Cytokines in oncolytic virotherapy

Jonathan G Pol1, Samuel T Workenhe2, Prathyusha Konda3

  • 1Centre de Recherche des Cordeliers, Equipe 11 labellisée par la Ligue Nationale contre le Cancer, INSERM, Sorbonne Université, Université de Paris, Paris, France; Gustave Roussy Cancer Campus, Metabolomics and Cell Biology Platforms, Villejuif, France.

Cytokine & Growth Factor Reviews
|November 13, 2020
PubMed

Insights

Oncolytic viruses transform tumors into immune-friendly zones. These viruses promote cancer cell death, attracting immune cells to fight tumors effectively through oncolytic virotherapy.

Area of Science:

  • Immunology
  • Virology
  • Oncology

Background:

  • Tumors create hostile environments, suppressing anti-cancer immune cells.
  • Immune cells struggle to infiltrate tumors and eliminate cancer cells due to immunosuppressive factors.

Purpose of the Study:

  • To review how oncolytic viruses reshape the tumor microenvironment.
  • To identify key signaling molecules involved in oncolytic virotherapy's immune response.

Main Methods:

  • Review of scientific literature on oncolytic viruses and tumor immunology.
  • Analysis of signaling pathways and cellular interactions in the tumor microenvironment.

Main Results:

  • Oncolytic viruses induce immunogenic cancer cell death.
  • This process releases danger signals and antigens, attracting and activating immune cells.
  • Key cytokines and chemokines orchestrate leukocyte activity against tumors.

Conclusions:

  • Oncolytic virotherapy effectively reconditions the tumor microenvironment for anti-tumor immunity.
  • It enhances immune cell infiltration and cytotoxic activity, offering a promising cancer treatment strategy.
Keywords:
ChemokinesGrowth factorsInterferonsInterleukinsOncolytic virus

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