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Factors Affecting the Risk of Infection

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...

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Correlation Between Modic Changes and Bacterial Infection: A Causative Study.

Saurabh Singh¹, G I Siddhlingeswara¹, Alok Rai¹

¹Department of Orthopaedics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

International Journal of Spine Surgery

|November 13, 2020

Summary

This summary is machine-generated.

Bacterial infection may cause Modic changes (MC) in patients with chronic low back pain. A study found 90% of disc samples from patients with MC and back pain tested positive for bacteria using PCR.

Keywords:

MRI Modic changes PCR infection low back pain

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Area of Science:

Spinal imaging and diagnostics
Microbiology and infectious diseases
Orthopedic research

Background:

Modic changes (MC) are frequently observed on MRI in individuals experiencing low back pain.
While degeneration and mechanical factors are common causes, an infectious etiology for MC is also being investigated.
Previous research suggests a potential link between Modic changes and bacterial infection.

Purpose of the Study:

To investigate the etiological correlation between Modic changes (MC) and bacterial infection.
To utilize 16S DNA sequencing for bacterial identification in patients with chronic low backache and MC.
To explore the role of bacterial infection in the development of Modic changes.

Main Methods:

A prospective, nonrandomized study involving 20 patients (age 20-65) with chronic low back pain and Modic changes on MRI.
Patients underwent blood tests for leucocytosis, erythrocyte sedimentation rate, and C-reactive protein.
Intervertebral disc samples from discectomy were analyzed using polymerase chain reaction (PCR) targeting 16S ribosomal DNA for bacterial detection.

Main Results:

90% of disc samples from patients with low back pain and Modic changes tested positive for bacteria via PCR.
Elevated inflammatory markers were observed: 13.5% showed raised leucocytosis, 28.6% raised ESR, and 72.7% raised CRP.
The high prevalence of bacterial DNA in disc samples suggests a significant infectious component.

Conclusions:

Modic changes may be associated with an infective etiology.
Bacterial infection is a potential contributing factor to the development of Modic changes in the spine.
Further research is warranted to confirm the role of infection in Modic changes and low back pain.