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Related Concept Videos

Analgesia and Pain Management01:25

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Pain01:20

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Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
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Regional Terms01:12

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Regional terms describe anatomy by dividing the body parts into different regions that contain structures involved in contributing similar functions. Using these terms helps increase the accurate description and identification of the particular region of interest or region affected by the disease.
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Updated: Nov 30, 2025

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
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Complex regional pain syndrome: an evolving perspective.

Steven Cutts1, Shafat Gangoo2, Sriram Harish Srinivasan2

  • 1Orthopaedics, James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, UK stevenfrcs@hotmail.com.

Postgraduate Medical Journal
|November 13, 2020
PubMed
Summary
This summary is machine-generated.

Complex regional pain syndrome (CRPS) is a poorly understood condition often disproportionate to injury. This review examines its evolving understanding, pathogenesis, and treatments for clinicians.

Keywords:
Basic sciencesinternal medicineneurologypathology

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Area of Science:

  • Neurology
  • Pain Medicine
  • Medical Research

Background:

  • Complex regional pain syndrome (CRPS) is a poorly understood, heterogeneous condition often triggered by minor injuries.
  • Symptoms persist long after the initial injury, sometimes linked to peripheral nerve damage.
  • The disability can be disproportionate to the inciting event, leading to prolonged recovery.

Observation:

  • Diagnostic criteria for CRPS have evolved significantly over two centuries.
  • Historical literature presents challenges for comparison with contemporary research.
  • A national expert in peripheral nerve injury contributed to this review.

Findings:

  • This review synthesizes current understanding of CRPS evolution and pathogenesis.
  • It addresses the condition's heterogeneity, diagnostic challenges, and treatment options.
  • The article facilitates comparison between historical and recent CRPS research.

Implications:

  • Improved understanding of CRPS pathogenesis can guide future research.
  • Clarifying diagnostic criteria aids clinical practice and patient management.
  • This review provides clinicians with updated insights into CRPS investigations and treatments.