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COVID-19 associated variations in liver function parameters: a retrospective study.

Ram Krishan Saini1, Neha Saini1, Sant Ram1

  • 1Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Postgraduate Medical Journal
|November 13, 2020
PubMed
Summary
This summary is machine-generated.

Over half of hospitalized COVID-19 patients show abnormal liver function, linked to elevated inflammatory markers. This liver injury is more common in elderly males and indicates a higher risk of severe disease progression.

Keywords:
Basic sciencesBiochemistryClinical chemistryHepatologyInternal medicinePathologyPublic health

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Area of Science:

  • Hepatology
  • Virology
  • Clinical Medicine

Background:

  • Laboratory findings in COVID-19 patients are crucial for diagnosis and treatment.
  • Limited studies correlate hepatic profile variations with inflammatory markers in SARS-CoV-2 infections.

Purpose of the Study:

  • To investigate the correlation between liver function tests and inflammatory markers in COVID-19 patients.
  • To identify the prevalence and characteristics of liver injury in hospitalized SARS-CoV-2 patients.

Main Methods:

  • Retrospective analysis of liver function tests and inflammatory markers in 170 confirmed COVID-19 patients.
  • Data collected from a tertiary care center using Roche Cobas Autoanalyzer.

Main Results:

  • 58.5% of patients had abnormal liver enzymes; 48.31% experienced liver injury, associated with increased ICU need (p=0.0005).
  • Abnormal liver enzymes and injury were significantly linked to older age (p<0.0001) and male gender (p=0.004).
  • Elevated inflammatory markers (CRP, ferritin) correlated positively with liver function parameters.

Conclusions:

  • Abnormal liver function is prevalent in over half of hospitalized COVID-19 patients, associated with heightened inflammatory markers.
  • Elderly males with abnormal liver function face a higher risk of severe COVID-19 disease.
  • Liver injury in COVID-19 patients is linked to specific inflammatory markers and demographic factors.