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Updated: Nov 30, 2025

Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations
Published on: January 4, 2018
Enabling protein-hosted organocatalytic transformations
Alexander R Nödling1, Nicolò Santi1, Thomas L Williams1
1School of Chemistry, Cardiff University, Main Building, Cardiff, CF10 3AT, UK.
Abstract:
In this review, the development of organocatalytic artificial enzymes will be discussed. This area of protein engineering research has underlying importance, as it enhances the biocompatibility of organocatalysis for applications in chemical and synthetic biology research whilst expanding the catalytic repertoire of enzymes. The approaches towards the preparation of organocatalytic artificial enzymes, techniques used to improve their performance (selectivity and reactivity) as well as examples of their applications are presented. Challenges and opportunities are also discussed.
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