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Updated: Nov 30, 2025
An In Vitro Approach to Photodynamic Therapy
Published on: August 17, 2018
Self-reporting heavy atom-free photodynamic therapy agents
Gulsen Turkoglu1, Gozde Kayadibi Koygun2, Mediha Nur Zafer Yurt3
1Research and Development Center for Diagnostic Kits (KIT-ARGEM) Konya Food and Agriculture University, 42080, Konya, Turkey and Konya Food and Agriculture University, Department of Molecular Biology and Genetics, 42080, Konya, Turkey. sundus.erbascakmak@gidatarim.edu.tr.
Abstract:
Two novel, self-reporting distyryl BODIPY-based photodynamic therapy agents functionalized with singlet oxygen responsive imidazole and tertiary amine moieties are developed. Heavy atom-free photosensitizers are demonstrated to have efficient photodynamic action in MCF7 cells. The fluorescence intensity of the photosensitizers is shown to be reduced as a result of 1O2 generation without any significant change in photodynamic activity.
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