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Arteriolar oxygen reactivity: where is the sensor?

W F Jackson1

  • 1Department of Physiology, Medical College of Georgia, Augusta 30912.

The American Journal of Physiology
|November 1, 1987
PubMed
Summary

Arterioles are not intrinsically sensitive to oxygen. Instead, oxygen sensors in downstream vessels or tissues likely regulate arteriolar diameter via conducted responses.

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Area of Science:

  • Physiology
  • Vascular Biology
  • Respiratory Physiology

Background:

  • Arteriolar tone regulation is crucial for tissue oxygenation.
  • Intrinsic oxygen sensitivity of arterioles is a proposed mechanism.

Purpose of the Study:

  • To test the hypothesis that arterioles are intrinsically sensitive to oxygen.
  • To differentiate between local and global oxygen partial pressure (PO2) effects on arteriolar diameter.

Main Methods:

  • Superfused hamster cheek pouch preparations were used.
  • Local PO2 changes were induced by microapplication or in situ perfusion.
  • Global PO2 changes were achieved via superfusate modification.

Main Results:

  • Local PO2 changes did not significantly alter arteriolar diameter.
  • Global PO2 changes induced significant and reproducible arteriolar diameter modifications.
  • These findings do not support intrinsic arteriolar oxygen sensitivity.

Conclusions:

  • Oxygen sensors are likely located downstream of 15-micron arterioles (e.g., capillaries, venules) or within the parenchyma.
  • Detected PO2 changes initiate conducted responses along the vasculature to distant arterioles.

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