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Updated: Nov 30, 2025

Culturing Primary Rat Inner Medullary Collecting Duct Cells
Published on: June 21, 2013
[Advances in research on aquaporins in medical helminthes]
1Department of Pathogenic Biology, Basic Medical College, Chongqing Medical University, Chongqing 400016, China.
Abstract:
Aquaporins (AQPs) are a class of membrane intrinsic proteins in medical helminthes that specifically mediate the transmembrane transport of water or other solute molecules. Previous studies have demonstrated that AQPs play a critical role in promoting the transmembrane transport of water, osmoregulation, uptake of nutrients, release of toxic metabolic products and transport of antiparasitic drugs, which may serve as promising vaccine candidates and drug targets for parasitic diseases. This review describes the structural characteristics of AQPs in medical helminthes, and discusses the feasibility of these AQPs as antihelminth vaccine candidates and drug targets, so as to provide insights into the development of novel vaccines and drugs against parasitic diseases.
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