Related Experiment Video
Updated: Nov 30, 2025
Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
Coronary remodeling and biomechanics: Are we going with the flow in 2020?
Patricia E McCallinhart1, Benjamin W Scandling2,3, Aaron J Trask1,4
1Center for Cardiovascular Research, The Heart Center, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio.
Insights
Coronary blood flow (CBF) is regulated by metabolites and neurohormones. Emerging evidence suggests cardiac biomechanics and extravascular compression also significantly impact CBF, especially in disease.
Area of Science:
- Cardiovascular Physiology
- Biomedical Engineering
Background:
- Coronary blood flow (CBF) is essential for myocardial metabolic demands.
- Known regulators include local metabolites and neurohormonal factors.
- In conditions like diabetes and ischemia, CBF regulation is impaired.
Purpose of the Study:
- To review established and emerging regulators of CBF.
- To discuss the role of coronary structure and cardiac biomechanics.
- To explore the influence of extravascular compression on CBF control.
Main Methods:
- Mini-review of existing literature.
- Discussion of physiological and pathophysiological conditions.
- Synthesis of functional, structural, and biomechanical factors.
Main Results:
- Traditional regulators (metabolites, neurohormones) are well-studied.
- Coronary structure and biomechanics are increasingly recognized as critical.
- Extravascular compression significantly influences CBF dynamics.
Conclusions:
- CBF regulation is multifactorial, involving more than just metabolic and neurohormonal control.
- Cardiac biomechanics and extravascular forces are key determinants of CBF.
- Understanding these factors is crucial for managing cardiovascular diseases.
Abstract:
Under normal conditions, coronary blood flow (CBF) provides critical blood supply to the myocardium so that it can appropriately meet the metabolic demands of the body. Dogmatically, there exist several known regulators and modulators of CBF that include local metabolites and neurohormonal factors that can influence the function of the coronary circulation. In disease states such as diabetes and myocardial ischemia, these regulators are impaired or shifted such that CBF is reduced. Although functional considerations have been and continued to be well studied, more recent evidence builds upon established studies that collectively suggest that the relative roles of coronary structure, biomechanics, and the influence of cardiac biomechanics via extravascular compression may also play a significant role in dictating CBF. In this mini review, we discuss these regulators of CBF under normal and pathophysiological conditions and their potential influence on the control of CBF.
More Related Videos
06:39Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
Published on: April 13, 2015
06:18Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery
Published on: December 6, 2024
Related Concept Videos
01:26Coronary Artery Disease II: Pathophysiology
01:21Coronary Circulation
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
01:29Pathophysiology of Cardiac Performance