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Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Related Experiment Video

Updated: Nov 30, 2025

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
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Risk factors for candidaemia: A prospective multi-centre case-control study.

Caitlin Livia Keighley1,2,3, Alun Pope4, Deborah J E Marriott5

  • 1Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, New South Wales Health Pathology, Sydney, NSW, Australia.

Mycoses
|November 13, 2020
PubMed
Summary

Identifying risk factors for candidaemia (Candida bloodstream infections) is crucial due to high mortality. Key factors include weakened immune function, organ transplants, invasive devices, and carbapenem antibiotic use.

Keywords:
CandidaCandida spp.candidaemiacandidemiacandidiasisdeep fungal infectionfungemiaimmunodeficiency

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Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Epidemiology

Background:

  • Candidaemia presents a significant threat with up to 40% mortality, often linked to complex medical interventions.
  • Understanding the specific risk factors is essential for developing effective prevention and treatment strategies.

Purpose of the Study:

  • To identify and analyze the key risk factors associated with the development of candidaemia in adult patients.

Main Methods:

  • A prospective, multi-centre, case-control study was conducted over 12 months.
  • 118 cases of candidaemia were matched with 236 controls based on age, admission unit, and duration.

Main Results:

  • Multivariate analysis revealed significant risk factors including neutropenia, solid organ transplant, severe liver, respiratory, or cardiovascular disease.
  • Other identified risks were recent gastrointestinal, biliary, or urological surgery, central venous access devices, intravenous drug use, urinary catheters, and carbapenem use.

Conclusions:

  • Risk factors for candidaemia encompass infection source, carbapenem administration, compromised host immunity, and organ-specific comorbidities.
  • Preventive measures should focus on mitigating iatrogenic disruption of mucocutaneous barriers and addressing intravenous drug use.