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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Coronary Artery Disease I: Introduction01:30

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Atherosclerosis III: Management01:26

Atherosclerosis III: Management

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Related Experiment Video

Updated: Nov 30, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

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[Prostate cancer and atherosclerosis].

E V Pomeshkin1,2, A I Bragin-Maltsev2, S A Pomeshkina3

  • 1Federal State Budgetary Educational Institution of Higher Education Kemerovo State Medical University, the Ministry of Healthcare of the Russian Federation, Kemerovo, Russia.

Urologiia (Moscow, Russia : 1999)
|November 13, 2020
PubMed
Summary

Prostate cancer (PCa) and coronary artery disease (CAD) share risk factors like high cholesterol. Atherosclerosis patients may benefit from PCa screening, and PCa patients should be checked for cardiovascular risks. Statins may help both conditions.

Keywords:
atherosclerosiscoronary artery diseaseprostate cancer

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Area of Science:

  • Oncology and Cardiology
  • Public Health

Background:

  • Prostate cancer (PCa) is a significant cause of morbidity and mortality globally.
  • Coronary artery disease (CAD), driven by atherosclerosis, is the leading cause of death worldwide.
  • The interplay between risk factors for PCa and CAD warrants investigation.

Purpose of the Study:

  • To review the interaction between risk factors for prostate cancer and coronary artery disease.
  • To explore the potential for shared screening and treatment strategies.

Main Methods:

  • Literature review focusing on modifiable and non-modifiable risk factors.
  • Analysis of the association between serum cholesterol, atherosclerosis, and PCa.
  • Discussion of the potential role of statins.

Main Results:

  • Elevated serum cholesterol is linked to both CAD and PCa development/progression.
  • Patients with atherosclerosis could be a target group for PCa screening.
  • PCa patients may require screening for cardiovascular diseases and risk factors.

Conclusions:

  • Shared risk factors suggest a link between atherosclerosis and prostate cancer.
  • Screening and risk factor management should be considered for patients with either condition.
  • Statins show potential benefits for atherosclerosis and may reduce PCa risk.