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Related Experiment Video

Updated: Nov 30, 2025

Synthesis of Phase-shift Nanoemulsions with Narrow Size Distributions for Acoustic Droplet Vaporization and Bubble-enhanced Ultrasound-mediated Ablation
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CDCP1-targeted nanoparticles encapsulating phase-shift perfluorohexan for molecular US imaging in vitro.

Meng Zhao1, Yunkai Zhu2, Yanhua Zhang1

  • 1State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.

Clinical Hemorheology and Microcirculation
|November 13, 2020
PubMed
Summary

New targeted nanoparticles show promise for enhanced ultrasound imaging in prostate cancer detection. These agents demonstrated effective tumor targeting and improved image clarity in vitro, paving the way for future in vivo applications.

Keywords:
Targeted nanoparticlecontrast agentprostate cancer

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Area of Science:

  • Nanotechnology
  • Biomedical Imaging
  • Oncology

Background:

  • Molecular targeted contrast-enhanced ultrasound (CEUS) imaging offers improved diagnostic accuracy over conventional ultrasound (US).
  • Nano-sized targeted agents with phase-shift materials show superior molecular imaging potential compared to traditional micrometer-sized gas bubbles.

Purpose of the Study:

  • To develop and assess novel CDCP1 receptor-targeted nanoparticles (anti-CDCP1 NPs) for enhanced ultrasound imaging in prostate cancer detection.
  • To evaluate the in vitro performance, including cytotoxicity and targeting ability, of these targeted nanoparticles as contrast agents.

Main Methods:

  • PLGA, DSPE-mPEG2k, and perfluorohexan (PFH) were used to create CDCP1-targeted nanoparticles (anti-CDCP1 NPs).
  • In vitro studies assessed nanoparticle cytotoxicity, CEUS imaging enhancement, and targeting efficacy in cells expressing CDCP1.
  • Ultrasound (US) was utilized to assist in evaluating the targeting ability of the anti-CDCP1 NPs.

Main Results:

  • Anti-CDCP1 NPs exhibited low cytotoxicity.
  • CEUS imaging enhancement increased with polymer concentration and observation time.
  • Active targeting of CDCP1-expressing cells by anti-CDCP1 NPs was confirmed in vitro.

Conclusions:

  • The in vitro feasibility of using targeted anti-CDCP1 NPs to enhance ultrasound imaging was demonstrated.
  • These findings provide a foundation for in vivo molecular US imaging.
  • Anti-CDCP1 NPs hold significant potential for future clinical applications in prostate cancer diagnosis.