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Related Concept Videos

Applications Of NMR In Biology01:25

Applications Of NMR In Biology

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Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
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Drug Discovery: Overview01:26

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Structure-Activity Relationships and Drug Design01:28

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Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
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Nuclear Magnetic Resonance (NMR): Overview01:07

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Nuclear magnetic resonance (NMR) is a phenomenon exhibited by certain nuclei that can absorb characteristic radio frequency radiation under certain conditions. NMR has been extensively applied in molecular spectroscopy and medical diagnostic imaging. In both these applications, the molecule or subject under study is placed in a magnetic field and irradiated with radio frequency energy.
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...
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Other Nuclides: 31P, 19F, 15N NMR01:16

Other Nuclides: 31P, 19F, 15N NMR

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Many organic, inorganic, and biological molecules contain spin-half nuclei such as nitrogen-15, fluorine-19, and phosphorus-31. As a result, NMR studies of these nuclei have found extensive applications in chemical and biological research.
While fluorine-19 and phosphorous-31 have high natural abundances (100%) and positive gyromagnetic ratios, nitrogen-15 has a low natural abundance and a negative gyromagnetic ratio. However, nitrogen-15 is still preferred over nitrogen-14 (which has a...
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Preclinical Development: Overview01:28

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Updated: Nov 30, 2025

NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode
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Correction to: NMR in pharmaceutical discovery and development.

Raymond S Norton1,2, Wolfgang Jahnke3

  • 1Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC, 3052, Australia. ray.norton@monash.edu.

Journal of Biomolecular NMR
|November 13, 2020
PubMed
Summary

This article discusses the utility of fluorine Nuclear Magnetic Resonance (NMR) spectroscopy in biological systems. It highlights fluorine NMR as a valuable tool for pharmaceutical discovery and development.

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Area of Science:

  • Biophysical Chemistry
  • Chemical Biology

Context:

  • The article was intended for a special issue on NMR in Pharmaceutical Discovery and Development.
  • A publisher error led to its earlier publication in a different issue.
  • The article has been updated with the correct ORCID ID for author Wolfgang Jahnke.

Purpose:

  • To highlight the significance of fluorine Nuclear Magnetic Resonance (NMR) in studying biological systems.
  • To showcase the applications of fluorine NMR in pharmaceutical research and development.

Summary:

  • This work emphasizes the importance of fluorine NMR spectroscopy for analyzing biological systems.
  • It details the precious role of fluorine atoms in molecular imaging and drug discovery.
  • The study provides insights into leveraging fluorine NMR for enhanced understanding of biomolecular interactions.

Impact:

  • Facilitates advancements in pharmaceutical discovery and development through innovative NMR techniques.
  • Enhances the understanding of molecular mechanisms in biological systems.
  • Provides a valuable resource for researchers utilizing fluorine NMR in life sciences.