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Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
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Diabetes and Bone Fragility.

Camila Romero-Díaz1, Daniela Duarte-Montero1, Sebastián A Gutiérrez-Romero1

  • 1School of Medicine, Universidad de los Andes, Bogotá, Colombia.

Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders
|November 13, 2020
PubMed
Summary
This summary is machine-generated.

Diabetes significantly increases fracture risk in both type 1 (T1D) and type 2 (T2D) through distinct mechanisms. Early monitoring and treatment of bone health alongside diabetes management can reduce this risk.

Keywords:
BoneBonesDenosumabDiabetes mellitusFracturesOsteoporosis

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Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Bone Biology

Background:

  • Diabetes mellitus is a global health concern affecting multiple organ systems.
  • Bone health complications are often overlooked in diabetes management.
  • Both type 1 (T1D) and type 2 diabetes (T2D) are linked to increased fracture risk.

Purpose of the Study:

  • To review the mechanistic, epidemiological, and clinical evidence connecting diabetes with bone fragility.
  • To describe how diabetes treatments influence bone health.

Main Methods:

  • Review of existing literature on diabetes and bone health.
  • Analysis of mechanistic pathways linking hyperglycemia to bone microarchitecture and density.
  • Examination of epidemiological data on fracture risk in diabetic populations.

Main Results:

  • T1D leads to reduced bone mineral density (BMD) due to insulin deficiency.
  • T2D is associated with normal or high BMD but increased fracture risk from altered bone microarchitecture and osteoclast activity.
  • Chronic hyperglycemia causes collagen glycation, impairing bone quality in both T1D and T2D.

Conclusions:

  • Diabetes poses a significant threat to bone health, increasing fracture risk.
  • Effective management of diabetes and bone health conditions like osteopenia or osteoporosis is crucial.
  • Intervention strategies can substantially mitigate the elevated fracture risk in diabetic patients.