Related Experiment Video
Updated: Nov 30, 2025
Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
Chest CT features and progression of patients with coronavirus disease 2019
Linjun Xie1, Keke Hou2, Huayan Xu1
1Department of Radiology; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education; West China Second University Hospital, Sichuan University;20# South Renmin Road, Chengdu, Sichuan 610041, China.
Insights
Chest CT scans reveal distinct patterns in COVID-19 patients, with severe cases showing more extensive lung lesions. CT severity and MuLBSTA scores can aid in assessing disease progression and outcomes.
Area of Science:
- Radiology
- Infectious Diseases
- Pulmonology
Background:
- Coronavirus disease 2019 (COVID-19) is a significant global health threat.
- Understanding the radiological manifestations and disease progression is crucial for patient management.
Purpose of the Study:
- To investigate chest CT findings in COVID-19 patients.
- To evaluate the progression of COVID-19 based on CT imaging.
- To compare CT features across different severity types of COVID-19.
Main Methods:
- Retrospective analysis of chest CT scans from 49 adult COVID-19 patients.
- Evaluation of thin-section chest CT features and disease progression.
- Comparison of clinical and imaging findings between common, severe, and critically severe COVID-19 cases.
- Calculation of CT severity score and MuLBSTA score for mortality risk prediction.
Main Results:
- Severe COVID-19 cases showed significantly more GGO with consolidation and fibrosis compared to common cases.
- Severe cases exhibited higher CT severity and MuLBSTA scores, correlating with ICU admission.
- CT follow-up scans demonstrated progressive improvement in lung lesions over time.
Conclusions:
- Chest CT is valuable for assessing COVID-19 radiographical features and disease dynamics.
- CT severity score and MuLBSTA score can assist in evaluating COVID-19 severity and progression.
- The MuLBSTA score may require updates to incorporate COVID-19-related coagulation disorders.
Objectives:
Coronavirus disease 2019 (COVID-19) is a major public health emergency. It poses a grave threat to human life and health. The purpose of the study is to investigate the chest CT findings and progression of the disease observed in COVID-19 patients.
Methods:
Forty-nine confirmed cases of adult COVID-19 patients with common type, severe and critically severe type were included in this retrospective single-center study. The thin-section chest CT features and progress of the disease were evaluated. The clinical and chest imaging findings of COVID-19 patients with different severity types were compared. The CT severity score and MuLBSTA score (a prediction of mortality risk) were calculated in those patients.
Results:
Among the 49 patients, 35 patients (71%) were common type and 14 patients (28%) were severe and critically severe type. Nearly all patients (98%) had pure ground-glass opacities (GGO) in CT imaging. Of the severe and critically severe type patients, 86% exhibited GGO with consolidation, in comparison with 54% of the patients with common type. Fibrosis presented in 79% of the severe and critically severe type patients and 43% of the common type patients. The severe and critically severe type patients were significantly more prone to experience five-lobe involvement compared to the common type patients (p = 0.002). The severe and critically severe type patients also had higher CT severity and MuLBSTA scores than the common type patients (5.43 ± 2.38 vs 3.37 ± 2.40, p < 0.001;and 10.21 ± 3.83 vs 4.63 ± 3.43, p < 0.001, respectively). MuLBSTA score was positively correlated with admittance to the intensive care unit (p = 0.005, r = 0.351). Nineteen patients underwent three times CT scan. The interval between first and second CT scan was 4[4,8] days, second and third was 3[2,4] days. There were greater improvements in the third CT follow-up findings compared to the second (p = 0.002).
Conclusions:
The severe and critically severe type patients often experienced more severe lung lesions, including GGO with consolidation. The CT severity score and MuLBSTA score may be helpful for the assessment of COVID-19 severity and progression.
Advances In Knowledge:
Chest CT has the value of evaluated radiographical features of COVID-19 and allow for dynamic observation of the disease progression. Considering coagulation disorder of COVID-19, MuLBSTA score may need to be updated to increase new understanding of COVID-19.
More Related Videos
Related Concept Videos
01:20COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
01:29Chronic Obstructive Pulmonary Disease-V: Management
Smoking Cessation
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
01:20Chronic Obstructive Pulmonary Disease-I: Introduction