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Published on: September 29, 2017
Biomarkers in diabetic neuropathy
Kaveri M Adki1, Yogesh A Kulkarni1
1Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, Mumbai, India.
Diabetic neuropathy biomarkers, including inflammatory and oxidative markers, are crucial for early diagnosis and developing new treatments. Identifying these key indicators aids in halting disease progression.
Area of Science:
- Neurology
- Endocrinology
- Biochemistry
Background:
- Diabetic neuropathy prevalence is rising globally.
- There's a critical need for diagnostic biomarkers and novel drug targets to manage the condition.
Purpose of the Study:
- To investigate diverse biomarkers implicated in the pathogenesis of diabetic neuropathy.
- To identify potential targets for therapeutic intervention.
Main Methods:
- Comprehensive literature search conducted across major scientific databases (PubMed, Scopus, etc.) from 1976 to 2020.
- Systematic review and categorization of identified biomarkers.
Main Results:
- Biomarkers identified include inflammatory (MCP-1, VEGF), oxidative (adiponectin), enzyme-related (NADPH, DPP-4), and miscellaneous (SIRT1, microRNA) types.
- All categorized biomarkers play a significant role in diabetic neuropathy pathogenesis.
Conclusions:
- The identified biomarkers are pivotal in the progression of diabetic neuropathy.
- These biomarkers represent promising targets for future drug discovery and therapeutic strategies.
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