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Real-Time Control of Nanoparticle-Mediated Thermal Therapy Using Photoacoustic Imaging.

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    This study demonstrates that photoacoustic (PA) thermometry can effectively control temperature during nanoparticle-mediated hyperthermia treatments. A commercial PA imaging system enabled precise temperature management in ex-vivo tissue, enhancing treatment safety and efficacy.

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    Area of Science:

    • Biomedical Engineering
    • Medical Imaging
    • Theranostics

    Background:

    • Precise temperature monitoring and control are crucial for effective and safe thermal therapies.
    • Nanoparticle-mediated hyperthermia offers targeted therapeutic potential but requires accurate thermal management.
    • Photoacoustic (PA) imaging provides non-invasive visualization capabilities that may be leveraged for temperature feedback.

    Purpose of the Study:

    • To evaluate the feasibility of using a commercial photoacoustic (PA) imaging system for real-time temperature control in nanoparticle-mediated thermal therapies.
    • To develop and validate a PA-based closed-loop controller for hyperthermia treatments.
    • To assess the accuracy and stability of PA thermometry in controlling therapeutic temperatures.

    Main Methods:

    • A commercial PA imaging system was adapted to acquire real-time temperature maps from ex-vivo tissue.
    • PA thermometry was calibrated and validated against a fluoroptic thermometer.
    • A software-based proportional-integral-derivative (PID) controller was developed and implemented using PA temperature feedback for gold nanorod (GNR) mediated laser therapy.

    Main Results:

    • Gold nanorod (GNR) injection significantly enhanced laser heating, increasing temperature rise sevenfold.
    • The PA-based closed-loop controller successfully achieved and maintained desired temperatures at targeted locations in ex-vivo tissue.
    • Steady-state mean absolute deviations from the target temperature ranged from 0.16°C to 0.5°C, demonstrating precise control.

    Conclusions:

    • Commercial photoacoustic (PA) imaging systems can be effectively utilized with PID controllers for precise temperature management in hyperthermia treatments.
    • This non-invasive, easily implemented system facilitates accurate temperature delivery to target tissues while sparing surrounding healthy areas.
    • The developed PA thermometry control system shows significant promise for advancing the clinical application of various hyperthermia treatments.