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Updated: Nov 30, 2025

Characterizing Mutational Load and Clonal Composition of Human Blood
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Genetic heterogeneity and clonal evolution in acute myeloid leukemia

Jennifer S Romer-Seibert1, Sara E Meyer

  • 1Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Current Opinion in Hematology
|November 13, 2020
PubMed
Summary

Single-cell sequencing reveals the complex clonal diversity in acute myeloid leukemia (AML). This genetic heterogeneity presents a major challenge for effective AML treatment strategies.

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