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Treatment of a Large Multiloculated Liver Abscess with Intra-Abscess Antibiotic Instillation
1From the Department of Pediatrics, University of Queensland School of Medicine, Ochsner Clinical School, Ochsner Hospital for Children.
Abstract:
This report describes a 15-year-old with an 11.1 × 8.2 × 8.4 cm multiloculated liver abscess caused by methicillin-sensitive Staphylococcus aureus who failed extensive catheter drainage and intravenous antibiotics. Daily intra-abscess oxacillin was instilled for 7 days with rapid clinical improvement and sterilization of the abscess. One month later, an ultrasound of the abdomen revealed a normal liver.
Insights
A large liver abscess caused by Staphylococcus aureus was successfully treated with direct intra-abscess antibiotic instillation. This innovative approach led to rapid clinical improvement and abscess sterilization in a pediatric patient.
Area of Science:
- Medicine
- Infectious Diseases
- Pediatrics
Background:
- Liver abscesses can be challenging to treat, especially when standard therapies like antibiotics and drainage fail.
- Methicillin-sensitive Staphylococcus aureus (MSSA) is a common pathogen causing serious infections.
Observation:
- A 15-year-old patient presented with a large, multiloculated liver abscess (11.1 × 8.2 × 8.4 cm).
- The patient did not respond to extensive catheter drainage and intravenous antibiotics.
Findings:
- Daily intra-abscess instillation of oxacillin for 7 days was administered.
- This targeted therapy resulted in rapid clinical improvement and effective sterilization of the abscess.
Implications:
- Intra-abscess antibiotic instillation offers a promising alternative treatment for refractory liver abscesses.
- This method may be particularly useful in pediatric cases where conventional treatments are insufficient.
- Further research into localized antibiotic delivery for complex infections is warranted.
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