Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Nov 30, 2025

Nanosponge Tunability in Size and Crosslinking Density

Nanosponge Tunability in Size and Crosslinking Density

Published on: August 4, 2017

Tuning cell behavior with nanoparticle shape.

Edoardo Scarpa¹, Cesare De Pace¹, Adrian Steve Joseph¹

¹Department of Chemistry, University College London, London, United Kingdom.

|November 13, 2020

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effects of Drugs for the Treatment of Multiple Sclerosis in Severe Acute Respiratory Syndrome Coronavirus 2 Infection on the Expression of Angiotensin-converting Enzyme 2 in vitro.

Current neuropharmacology·2026

Same author

Development of molecularly imprinted vegetarian membranes (MIP-VMs) for oral tissue repair and regeneration.

Frontiers in bioengineering and biotechnology·2026

Same author

CRISPR/Cas9-Mediated Gene Knockout Reveals a Nonredundant Role for p16<sup>INK4A</sup> in Controlling TCR-Dependent and Independent CD8 T Cell Expansion.

European journal of immunology·2026

Same author

Choroid plexus remodeling linked to impaired CSF-mediated clearance and Alzheimer's disease progression.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Same author

Endocytic turnover of endothelial cell-membrane proteins as a driver of rat blood-brain barrier specialization and dysfunction.

iScience·2026

Same author

Investigation of Magnesium Hydroxide as a Halogen-Free Fire-Retardant Filler for Advanced Polymer-Based Solutions: A Review.

Polymers·2026

Same journal

Analysis of strength degradation of coal and rock masses and stability of mined areas under long term immersion environment.

PloS one·2026

Same journal

Biogenic Silver-Selenium nanocomposite with anticancer activity and potent efficacy against vancomycin-resistant Staphylococcus aureus.

PloS one·2026

Same journal

Preparation and physicochemical characterization of a biodegradable chitosan/carboxymethyl cellulose hydrogel synthesized in NaOH/urea medium.

PloS one·2026

Same journal

Action-guilt, survivor-guilt, and depression in combat-related PTSD.

PloS one·2026

Same journal

Explainable machine learning for predicting activities of daily living at discharge in stroke patients: A retrospective study using SHAP interpretability.

PloS one·2026

Same journal

Deep learning based two-way feature depiction model for brain tumor detection.

PloS one·2026

See all related articles

This summary is machine-generated.

The shape of polymeric vesicles influences cancer cell replication. Tubular vesicles, unlike spherical ones, reduce cancer cell activity by up-regulating tumor suppressor genes and activating caspase 3/7.

Area of Science:

Biomaterials Science
Cell Biology
Nanotechnology

Background:

Polymeric vesicles (polymersomes) are promising for drug delivery.
The impact of nanoparticle shape on cellular behavior is not fully understood.
Understanding shape-dependent cellular interactions is crucial for targeted therapies.

Purpose of the Study:

To investigate how the shape of polymeric vesicles affects cancer and non-cancer cell replication and metabolic state.
To characterize cellular uptake and response to spherical versus tubular polymersomes.
To explore the potential of shape-tuned nanoparticles for enhanced drug delivery.

Main Methods:

Isolation of spherical and tubular polymersomes using density-gradient centrifugation.
Characterization of cellular internalization and uptake kinetics in cancer and non-cancer cells.

More Related Videos

Expanding Nanopatterned Substrates Using Stitch Technique for Nanotopographical Modulation of Cell Behavior

Expanding Nanopatterned Substrates Using Stitch Technique for Nanotopographical Modulation of Cell Behavior

Published on: December 8, 2016

Harmonic Nanoparticles for Regenerative Research

Harmonic Nanoparticles for Regenerative Research

Published on: May 1, 2014

Related Experiment Videos

Last Updated: Nov 30, 2025

Nanosponge Tunability in Size and Crosslinking Density

Nanosponge Tunability in Size and Crosslinking Density

Published on: August 4, 2017

Expanding Nanopatterned Substrates Using Stitch Technique for Nanotopographical Modulation of Cell Behavior

Expanding Nanopatterned Substrates Using Stitch Technique for Nanotopographical Modulation of Cell Behavior

Published on: December 8, 2016

Harmonic Nanoparticles for Regenerative Research

Harmonic Nanoparticles for Regenerative Research

Published on: May 1, 2014

Analysis of cellular metabolic response, gene expression (p21, p53), and caspase 3/7 activity.

Main Results:

Tubular vesicles significantly decreased cancer cell replication compared to spherical vesicles.
This effect was linked to p21 and p53 tumor suppressor gene up-regulation and caspase 3/7 activation.
Combining tubular vesicles with doxorubicin enhanced cytotoxicity.

Conclusions:

Polymersome geometry significantly impacts cancer cell behavior and metabolic state.
Shape-dependent effects can be leveraged for targeted cancer therapy.
This study highlights the potential of geometrically tailored nanoparticles for advanced drug delivery systems.