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Progress in research into the role of abnormal glycosylation modification in tumor immunity

Hui-Min Liu1, Le-le Ma1, Bo Cao1

  • 1Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.

Immunology Letters
|November 13, 2020
PubMed

Insights

Abnormal glycosylation, the incorrect attachment of carbohydrates to proteins, impacts tumor escape by altering immune cell and molecule function. This review explores the immunological link between aberrant glycosylation and tumor immune evasion strategies.

Area of Science:

  • Immunology
  • Glycobiology
  • Cancer Biology

Background:

  • Abnormal glycosylation involves the aberrant attachment of carbohydrates to proteins, leading to protein denaturation.
  • Altered protein glycosylation is implicated in tumor progression and immune evasion.
  • The specific impact of glycosylation changes on immune cell and molecule function in tumor escape remains underexplored.

Purpose of the Study:

  • To summarize the immunological effects of abnormal glycosylation on tumor escape.
  • To elucidate how altered glycosylation influences immune system components in the context of cancer.

Main Methods:

  • Literature review and synthesis of existing research.
  • Immunological perspective analysis of abnormal glycosylation's role in tumor escape.

Main Results:

  • Abnormal glycosylation directly and indirectly influences tumor escape mechanisms.
  • Changes in protein glycosylation can alter the structure and function of immune cells and molecules.
  • These alterations play a role in the regulation of tumor immune evasion.

Conclusions:

  • Abnormal glycosylation is a significant factor in tumor immune evasion.
  • Understanding these immunological links is crucial for developing novel cancer immunotherapies.
  • Further research is warranted to fully elucidate the complex interplay between glycosylation and anti-tumor immunity.
Keywords:
Abnormal glycosylationAntigen recognitionImmune systemTumor escape

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